Alzheimer’s disease has long been associated with the harmful proteins amyloid beta and tau. They clump up in the brain, disrupting neurons and causing memory loss and other symptoms. Researchers at Temple University’s Lewis Katz School of Medicine say they’ve found a new way to prevent amyloid beta and tau from building up in the […]
“This beautiful study shows, for the first time, a close association between T cells, cognition, and neurodegenerative disease in humans,” wrote Jonathan Kipnis of University of Virginia in Charlottesville. “These elegant findings on expansion of Epstein-Barr virus-reactive CD8 T cells in the CSF of AD patients are extremely interesting and intriguing,” he added. More at: […]
Patients with the ultra-rare disease FOP grow bone where it doesn’t belong, creating a life-threatening second skeleton. Regeneron Pharmaceuticals believes it can offer hope: A new treatment reduced new bone growth by 90% in a clinical trial, the company said, a result that could lead to Food and Drug Administration approval. More at: https://www.statnews.com/2020/01/09/regeneron-drug-reduces-bone-growth-rare-skeletal-disease/
UPDATED: Biogen’s Alzheimer’s drug aducanumab implodes in a PhIII disaster — putting them at a perilous crossroads More at https://endpts.com/biogens-alzheimers-drug-aducanumab-implodes-in-a-phiii-disaster/
She began seeing a physical therapist and stopped working out. Then in early 2017 came the limp — what the therapist termed “drop foot.” The next several months were filled with doctor visits, nerve tests, a broken leg and further weakening of Wittenberg’s limbs. By March of that year, the mother of two could no […]
Genetic mutations in two previously unrecognized genes, the microtubule-associated protein tau (MAPT) and BNIP1 genes, are associated with elevated risk for amyotrophic lateral sclerosis (ALS). The study with that finding “Selective genetic overlap between amyotrophic lateral sclerosis and diseases of the frontotemporal dementia spectrum,” was published in the journal JAMA Neurology. As seen in other neurodegenerative diseases, abnormal accumulation of […]
House Republicans failed Tuesday evening to pass a “right-to-try” bill that would give terminally ill patients access to experimental drugs without FDA authorization after failing to muster enough votes to approve it through an expedited process. The 259-140 vote fell short of the necessary two-thirds support from the House chamber. The failed vote is a […]