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Programming Gene Expression in Multicellular Organisms for Physiology Modulation Through Engineered Bacteria

Bacteria are fascinating little machines. In the past century, we have harnessed the power of bacteria to produce antibiotics, recombinant drugs, and food. We as humans have evolved and lived, sometimes symbiotically, with bacteria, i.e., in the case of intracellular mitochondria and cellular energy production. This same symbiosis is seen with the bacteria that line […]

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Losing Fat Through The Skin

In June, the FDA approved Wegovy for chronic weight management. This subcutaneous injection is the first approved drug for chronic weight management in adults with a high BMI and general obesity since 2014. With 70% of American adults being overweight or obese, there certainly seems to be room for new drug entrants to this growing […]

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Development of an Effective Non-Hormonal Female Contraception

Birth control is a universal term that encompasses everything from a physical barrier to the chemical inhibition of ovulation. The most common form of contraception, according to the CDC, is female sterilization. Excluding sterilization, the second and third most common forms of birth control are oral contraceptive pills and long-acting reversible contraceptives. The commonality of […]

AstraZeneca closes mega $39B Alexion buyout despite antitrust fears, making a splash in rare diseases

AstraZeneca’s mega $39 billion takeover of Alexion Pharmaceuticals has come to a close, delivering the British pharma a lucrative portfolio of immunology medicines and a towering presence in rare diseases. AZ on Wednesday announced the completion of its Alexion acquisition, a week after securing a pivotal nod from the U.K.’s Competition and Markets Authority (CMA). Industry watchers were concerned […]

NGM’s closely-watched NASH prospect flops, cutting shares in half and spurring R&D rethink

A phase 2b trial of NGM Biopharmaceuticals’ aldafermin in nonalcoholic steatohepatitis (NASH) has missed its primary endpoint, sending shares in the biotech tumbling. NGM has pulled plans to enter phase 3 in light of the midstage failure of the FGF19 analog. California-based NGM ramped up expectations for aldafermin last year when it delivered midphase data linking […]

Russia’s Sputnik V nabs first Twitter-verified vaccine handle, but is it PR or propaganda?

A blue check for Sputnik V—and a cautionary marketing tale for the pharma industry? The Russian-developed coronavirus vaccine nabbed verified status from Twitter last week, doubling down on its broadcasting wave of tweets, retweets and plenty of American-style attitude. But is the now-authenticated social media account a pharma influencer case study or a cautionary tale of disinformation? While […]