Intracellular Delivery of Protein Drugs Intracellular protein delivery is a daunting task that is near impossible due to the size and surface charge of proteins. However, protein macromolecule delivery is used in numerous disease states, such as monoclonal antibody therapeutics for cancer, autoimmune diseases, or asthma as well as the delivery of recombinant insulin to […]
Amazon has already changed the way we shop and filled our homes with “smart” gadgets, and now, the tech giant is looking to change the way we manage our health, both in the face of a pandemic and beyond. Amid the launch of its own wellness-tracking smartwatch and the expansion of the Amazon Care telehealth service, […]
Provention was flying high on Tuesday when an FDA advisory panel seemed to back the efficacy of its diabetes prevention drug, even after the agency flagged some issues with the data package supporting the therapy’s application a month earlier. But the company is not out of the woods yet, with the final vote only narrowly […]
The people who bring you lunch can now also deliver a COVID-19 diagnostic test, as screening for the pandemic disease continues to become a more ubiquitous part of everyday life. DoorDash has partnered up with the home-testing companies Everlywell and Vault Health to make sample collection kits available on-demand through its app, alongside sandwiches, pizza […]
Eli Lilly has shared full data from a phase 2 clinical trial it hailed as showing a “significant slowing of decline” in Alzheimer’s disease patients. The donanemab data are a mixed bag, with a slight win on one disease scale undermined by a failure on a more widely used measure of Alzheimer’s. In January, Lilly […]
Abstract BACKGROUND A hallmark of Alzheimer’s disease is the accumulation of amyloid-β (Aβ) peptide. Donanemab, an antibody that targets a modified form of deposited Aβ, is being investigated for the treatment of early Alzheimer’s disease…. … RESULTS A total of 257 patients were enrolled; 131 were assigned to receive donanemab and 126 to receive placebo. […]
A blue check for Sputnik V—and a cautionary marketing tale for the pharma industry? The Russian-developed coronavirus vaccine nabbed verified status from Twitter last week, doubling down on its broadcasting wave of tweets, retweets and plenty of American-style attitude. But is the now-authenticated social media account a pharma influencer case study or a cautionary tale of disinformation? While […]
Homozygous familial hypercholesterolemia (HoFH) is an ultra-rare inherited condition that affects approximately 1,300 patients in the U.S. and is characterized by extremely high low-density lipoprotein cholesterol (LDL-C) In pivotal Phase 3 HoFH trial, adding Evkeeza to standard lipid-lowering therapies reduced LDL-C by nearly half at 24 weeks, compared to placebo Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced that the U.S. […]
Novartis’ heart failure drug Entresto has been on the ascent after a slower-than-expected debut on the market, and now the drug has an expanded FDA label that could widen its reach to millions of new patients. The FDA on Tuesday endorsed Entresto—which already carried an OK in patients with chronic heart failure and reduced ejection fraction (HFrEF)—in heart failure with […]
Shares in Vir Biotechnology rose 74% on the strength of data from a blinded, eight-subject cohort in its phase 1 hepatitis B trial. The analysis suggests the neutralizing monoclonal antibody may be more potent than expected and provides a boost to Vir’s prospects of delivering a functional cure. Investigators enrolled eight patients with chronic hepatitis B virus […]